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  Promethazine is a medication used to manage and treat allergic conditions nausea and vomiting motion sickness and sedation. It also has offlabel uses for nausea and vomiting in pregnancy. Promethazine is a phenothiazine derivative with antidopaminergic antihistamine and anticholinergic properties. This activity reviews the FDA approvedindications mechanism of action administration Symptomatic relief of allergy such as hay fever and urticaria Insomnia associated with urticaria and pruritus. By mouth. Child years. mg twice daily alternatively mg once daily dose to be taken at night. Child years. mg twice daily alternatively mg once daily dose to be taken at night. Child years.